A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis
Identifieur interne : 002839 ( Main/Exploration ); précédent : 002838; suivant : 002840A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis
Auteurs : Yvonne J. Bryson [États-Unis] ; Carolyn Monahan [États-Unis] ; Melanie Pollack [États-Unis] ; W. Donald Shields [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1980.
Abstract
During a study of efficacy of amantadine prophylaxis of influenza A virus infection in young adults, gross and subtle side effects were monitored. Eighty-eight students were randomly selected to receive either amantadine or placebo for four weeks or both in a sequential crossover design of two weeks each. Side effects (i.e., dizziness, nervousness, and insomnia) occurred in 33% of those receiving amantadine and in 10% of those receiving placebo (P < 0.005). Although side effects were well tolerated by most subjects, six volunteers discontinued amantadine because of marked complaints. Cessation of side effects occurred in more than half of those continuing amantadine. Sixteen students receiving amantadine had decreased performance on sustained attention tasks as compared with ones receiving placebo (P < 0.05). Gross and subtle side effects of amantadine observed in this study on currently recommended dosage are higher than previously reported, which may be an important factor in consideration of mass prophylaxis.
Url:
DOI: 10.1093/infdis/141.5.543
Affiliations:
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Donald Shields</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5F5AB0CC442677121780DF6AEE8987AAC4D3CD1C</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1093/infdis/141.5.543</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-6FBJCLBG-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001265</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001265</idno><idno type="wicri:Area/Istex/Curation">001265</idno><idno type="wicri:Area/Istex/Checkpoint">001453</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001453</idno><idno type="wicri:doubleKey">0022-1899:1980:Bryson Y:a:prospective:double</idno><idno type="wicri:Area/Main/Merge">002986</idno><idno type="wicri:Area/Main/Curation">002839</idno><idno type="wicri:Area/Main/Exploration">002839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis</title><author><name sortKey="Bryson, Yvonne J" sort="Bryson, Yvonne J" uniqKey="Bryson Y" first="Yvonne J." last="Bryson">Yvonne J. Bryson</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Center for the Health Sciences, University of California, Los Angeles, School of Medicine, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Yvonne J. Bryson, Department of Pediatrics, Division of Infectious Diseases, Center for the Health Sciences, University of California, Los Angeles, School of Medicine, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Monahan, Carolyn" sort="Monahan, Carolyn" uniqKey="Monahan C" first="Carolyn" last="Monahan">Carolyn Monahan</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Center for the Health Sciences, University of California, Los Angeles, School of Medicine, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Pollack, Melanie" sort="Pollack, Melanie" uniqKey="Pollack M" first="Melanie" last="Pollack">Melanie Pollack</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Center for the Health Sciences, University of California, Los Angeles, School of Medicine, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Shields, W Donald" sort="Shields, W Donald" uniqKey="Shields W" first="W. Donald" last="Shields">W. Donald Shields</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Center for the Health Sciences, University of California, Los Angeles, School of Medicine, Los Angeles</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1980-05">1980</date><biblScope unit="vol">141</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="543">543</biblScope><biblScope unit="page" to="547">547</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">During a study of efficacy of amantadine prophylaxis of influenza A virus infection in young adults, gross and subtle side effects were monitored. Eighty-eight students were randomly selected to receive either amantadine or placebo for four weeks or both in a sequential crossover design of two weeks each. Side effects (i.e., dizziness, nervousness, and insomnia) occurred in 33% of those receiving amantadine and in 10% of those receiving placebo (P < 0.005). Although side effects were well tolerated by most subjects, six volunteers discontinued amantadine because of marked complaints. Cessation of side effects occurred in more than half of those continuing amantadine. Sixteen students receiving amantadine had decreased performance on sustained attention tasks as compared with ones receiving placebo (P < 0.05). Gross and subtle side effects of amantadine observed in this study on currently recommended dosage are higher than previously reported, which may be an important factor in consideration of mass prophylaxis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Bryson, Yvonne J" sort="Bryson, Yvonne J" uniqKey="Bryson Y" first="Yvonne J." last="Bryson">Yvonne J. Bryson</name></region><name sortKey="Bryson, Yvonne J" sort="Bryson, Yvonne J" uniqKey="Bryson Y" first="Yvonne J." last="Bryson">Yvonne J. 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